HMM Summary Page: TIGR02715

Functionamidohydrolase, AtzE family
Trusted Cutoff425.75
Domain Trusted Cutoff425.75
Noise Cutoff371.70
Domain Noise Cutoff371.70
Isology Typesubfamily
EC Number3.-.-.-
HMM Length452
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0016811: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function
AuthorHaft DH
Entry DateDec 1 2005 4:34PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are aminohydrolases related to, but distinct from, glutamyl-tRNA(Gln) amidotransferase subunit A. The best characterized member is the biuret hydrolase of Pseudomonas sp. ADP, which hydrolyzes ammonia from the three-nitrogen compound biuret to yield allophanate. Allophanate is also an intermediate in urea degradation by the urea carboxylase/allophanate hydrolase pathway, an alternative to urease.
ReferencesRN [1] RM 16085834 RT Allophanate hydrolase, not urease, functions in bacterial cyanuric acid metabolism. RA Cheng G, Shapir N, Sadowsky MJ, Wackett LP. RL Appl Environ Microbiol. 2005 Aug;71(8):4437-45.