HMM Summary Page: TIGR02713

Functionallophanate hydrolase
Gene SymbolatzF
Trusted Cutoff511.05
Domain Trusted Cutoff511.05
Noise Cutoff274.55
Domain Noise Cutoff274.55
Isology Typeequivalog
EC Number3.5.1.54
HMM Length563
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryNitrogen metabolism
Gene Ontology TermGO:0004039: allophanate hydrolase activity molecular_function
GO:0019627: urea metabolic process biological_process
AuthorHaft DH
Entry DateDec 1 2005 9:21AM
Last ModifiedFeb 14 2011 3:27PM
CommentAllophanate hydrolase catalyzes the second reaction in an ATP-dependent two-step degradation of urea to ammonia and C02, following the action of the biotin-containing urea carboxylase. The yeast enzyme, a fusion of allophanate hydrolase to urea carboxylase, is designated urea amidolyase.
ReferencesRN [1] RM 15901697 RT Purification and characterization of allophanate hydrolase (AtzF) from Pseudomonas sp. strain ADP. RA Shapir N, Sadowsky MJ, Wackett LP.' RL J Bacteriol. 2005 Jun;187(11):3731-8. RN [2] RM 15090492 RT Enzymatic characterization of a prokaryotic urea carboxylase. RA Kanamori T, Kanou N, Atomi H, Imanaka T. RL J Bacteriol. 2004 May;186(9):2532-9.
Genome PropertyGenProp0481: urea carboxylase/allophanate hydrolase pathway (HMM)