HMM Summary Page: TIGR02712

Functionurea carboxylase
Gene Symboluca
Trusted Cutoff1303.85
Domain Trusted Cutoff1303.85
Noise Cutoff655.90
Domain Noise Cutoff655.90
Isology Typeequivalog
EC Number6.3.4.6
HMM Length1201
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryNitrogen metabolism
Gene Ontology TermGO:0004847: urea carboxylase activity molecular_function
GO:0019627: urea metabolic process biological_process
AuthorHaft DH
Entry DateDec 1 2005 8:26AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are ATP-dependent urea carboxylase, including characterized members from Oleomonas sagaranensis (alpha class Proteobacterium) and yeasts such as Saccharomyces cerevisiae. The allophanate hydrolase domain of the yeast enzyme is not included in this model and is represented by an adjacent gene in Oleomonas sagaranensis. The fusion of urea carboxylase and allophanate hydrolase is designated urea amidolyase. The enzyme from Oleomonas sagaranensis was shown to be highly active on acetamide and formamide as well as urea.
ReferencesRM 15090492 RT Enzymatic characterization of a prokaryotic urea carboxylase. RA Kanamori T, Kanou N, Atomi H, Imanaka T. RL J Bacteriol. 2004 May;186(9):2532-9.
Genome PropertyGenProp0481: urea carboxylase/allophanate hydrolase pathway (HMM)