HMM Summary Page: TIGR02711

Functioncation/acetate symporter ActP
Gene SymbolactP
Trusted Cutoff1099.25
Domain Trusted Cutoff1099.25
Noise Cutoff893.30
Domain Noise Cutoff893.30
Isology Typeequivalog
HMM Length549
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0006814: sodium ion transport biological_process
GO:0015370: solute:sodium symporter activity molecular_function
GO:0031402: sodium ion binding molecular_function
AuthorHaft DH
Entry DateNov 30 2005 1:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family belong to the Sodium:solute symporter family. Both members of this family and other close homologs tend to be encoded next to a member of Pfam family PF04341, a set of uncharacterized membrane proteins. The characterized member from E. coli is encoded near and cotranscribed with the acetyl coenzyme A synthetase (acs) gene. Proximity to an acs gene was used as one criterion for determining the trusted cutoff for this model. Closely related proteins may differ in function and are excluded by the high cutoffs of this model; members of the family of phenylacetic acid transporter PhaJ can score as high as 1011 bits.
ReferencesDR PFAM; PF00474; SSF; Sodium:solute symporter family RN [1] RM 14563880 RT The gene yjcG, cotranscribed with the gene acs, encodes an acetate permease in Escherichia coli. RA Gimenez R, Nunez MF, Badia J, Aguilar J, Baldoma L. RL J Bacteriol. 2003 Nov;185(21):6448-55. DR HAMAP; MF_01426; 29 of 30