HMM Summary Page: TIGR02708
Accession | TIGR02708 |
Name | L_lactate_ox |
Function | L-lactate oxidase |
Gene Symbol | lctO |
Trusted Cutoff | 645.50 |
Domain Trusted Cutoff | 645.50 |
Noise Cutoff | 435.50 |
Domain Noise Cutoff | 435.50 |
Isology Type | equivalog |
EC Number | 1.1.3.- |
HMM Length | 367 |
Mainrole Category | Energy metabolism |
Subrole Category | Other |
Author | Haft DH |
Entry Date | Nov 28 2005 4:52PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this protein oxidize L-lactate to pyruvate, reducing molecular oxygen to hydrogen peroxide. The enzyme is known in Aerococcus viridans, Streptococcus iniae, and some strains of Streptococcus pyogenes where it appears to contribute to virulence. |
References | RN [1] RM 10508058 RT Cloning and analysis of the L-lactate utilization genes from Streptococcus iniae. RA Gibello A, Collins MD, Dominguez L, Fernandez-Garayzabal JF, Richardson PT. RL Appl Environ Microbiol. 1999 Oct;65(10):4346-50. RN [2] RM 12919327 RT Effect of mutations at Glu160 and Val198 on the thermostability of lactate oxidase. RA Minagawa H, Shimada J, Kaneko H. RL Eur J Biochem. 2003 Sep;270(17):3628-33. |