HMM Summary Page: TIGR02708

FunctionL-lactate oxidase
Gene SymbollctO
Trusted Cutoff645.50
Domain Trusted Cutoff645.50
Noise Cutoff435.50
Domain Noise Cutoff435.50
Isology Typeequivalog
EC Number1.1.3.-
HMM Length367
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
AuthorHaft DH
Entry DateNov 28 2005 4:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein oxidize L-lactate to pyruvate, reducing molecular oxygen to hydrogen peroxide. The enzyme is known in Aerococcus viridans, Streptococcus iniae, and some strains of Streptococcus pyogenes where it appears to contribute to virulence.
ReferencesRN [1] RM 10508058 RT Cloning and analysis of the L-lactate utilization genes from Streptococcus iniae. RA Gibello A, Collins MD, Dominguez L, Fernandez-Garayzabal JF, Richardson PT. RL Appl Environ Microbiol. 1999 Oct;65(10):4346-50. RN [2] RM 12919327 RT Effect of mutations at Glu160 and Val198 on the thermostability of lactate oxidase. RA Minagawa H, Shimada J, Kaneko H. RL Eur J Biochem. 2003 Sep;270(17):3628-33.