HMM Summary Page: TIGR02706

Functionphosphate butyryltransferase
Gene Symbolptb
Trusted Cutoff410.50
Domain Trusted Cutoff410.50
Noise Cutoff339.40
Domain Noise Cutoff339.40
Isology Typeequivalog
EC Number2.3.1.19
HMM Length294
Mainrole CategoryEnergy metabolism
Subrole CategoryFermentation
Gene Ontology TermGO:0006113: fermentation biological_process
GO:0050182: phosphate butyryltransferase activity molecular_function
AuthorHaft DH
Entry DateNov 28 2005 12:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are phosphate butyryltransferase, also called phosphotransbutyrylase. In general, this enzyme is found in butyrate-producing anaerobic bacteria, encoded next to the gene for butyrate kinase. Together, these two enzymes represent what may be the less common of two pathways for butyrate production from butyryl-CoA. The alternative is transfer of the CoA group to acetate by butyryl-CoA:acetate CoA transferase. Cutoffs for this model are set such that the homolog from Thermotoga maritima, whose activity on butyryl-CoA is only 30 % of its activity with acetyl-CoA, scores in the zone between trusted and noice cutoffs.
ReferencesDR PFAM; PF01515; PTA_PTB; Phosphate acetyl/butyryl transferase RN [1] RM 15028695 RT Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon. RA Louis P, Duncan SH, McCrae SI, Millar J, Jackson MS, Flint HJ. RL J Bacteriol. 2004 Apr;186(7):2099-106. RN [2] RM 10074080 RT Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima. RA Bock AK, Glasemacher J, Schmidt R, Schonheit P. RL J Bacteriol. 1999 Mar;181(6):1861-7.
Genome PropertyGenProp0910: butyryl-CoA to butyrate, phosphotransbutyrylase pathway (HMM)