HMM Summary Page: TIGR02705

Functionnucleoside triphosphatase YtkD
Gene SymbolytkD
Trusted Cutoff154.40
Domain Trusted Cutoff154.40
Noise Cutoff59.90
Domain Noise Cutoff59.90
Isology Typeequivalog
EC Number3.6.1.-
HMM Length156
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006139: nucleobase-containing compound metabolic process biological_process
GO:0017111: nucleoside-triphosphatase activity molecular_function
AuthorHaft DH
Entry DateNov 23 2005 12:39PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe functional assignment to the proteins of this family is contentious. Reference [2] challenges the findings of reference [1], both in interpretation and in enzyme assay results. This protein belongs to the nudix family and shares some sequence identity with E. coli MutT but appears not to be functionally interchangeable with it.
ReferencesDR PFAM; PF00293; NUDIX; hydrolase, NUDIX family DR SWISSPROT; O35013; Bacillus subtilis RN [1] RM 15576788 RT Gene ytkD of Bacillus subtilis encodes an atypical nucleoside triphosphatase member of the Nudix hydrolase superfamily. RA Xu W, Jones CR, Dunn CA, Bessman MJ. RL J Bacteriol. 2004 Dec;186(24):8380-4. RN [2] RM 14761999 RT The ytkD (mutTA) gene of Bacillus subtilis encodes a functional antimutator 8-Oxo-(dGTP/GTP)ase and is under dual control of sigma A and sigma F RNA polymerases. RA Ramirez MI, Castellanos-Juarez FX, Yasbin RE, Pedraza-Reyes M. RL J Bacteriol. 2004 Feb;186(4):1050-9.