HMM Summary Page: TIGR02702

Functioniron-sulfur cluster biosynthesis transcriptional regulator SufR
Gene SymbolsufR
Trusted Cutoff178.80
Domain Trusted Cutoff178.80
Noise Cutoff141.35
Domain Noise Cutoff141.35
Isology Typeequivalog
HMM Length208
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0016226: iron-sulfur cluster assembly biological_process
GO:0030528: transcription regulator activity molecular_function
GO:0045449: regulation of transcription biological_process
AuthorHaft DH
Entry DateNov 23 2005 11:02AM
Last ModifiedFeb 14 2011 3:27PM
CommentAll members of this cyanobacterial protein family are the transcriptional regulator SufR and regulate the SUF system, which makes possible iron-sulfur cluster biosynthesis despite exposure to oxygen. In all cases, the sufR gene is encoded near SUF system genes but in the opposite direction. This DNA-binding protein belongs to the the DeoR family of helix-loop-helix proteins. All members also have a probable metal-binding motif C-X(12)-C-X(13)-C-X(14)-C near the C-terminus.
ReferencesRM 14761990 RT The sufR gene (sll0088 in Synechocystis sp. strain PCC 6803) functions as a repressor of the sufBCDS operon in iron-sulfur cluster biogenesis in cyanobacteria. RA Wang T, Shen G, Balasubramanian R, McIntosh L, Bryant DA, Golbeck JH. RL J Bacteriol. 2004 Feb;186(4):956-67.
Genome PropertyGenProp0137: iron-sulfur cluster assembly SUF system (HMM)