HMM Summary Page: TIGR02698

Functioncopper transport repressor, CopY/TcrY family
Trusted Cutoff121.95
Domain Trusted Cutoff121.95
Noise Cutoff112.15
Domain Noise Cutoff112.15
Isology Typeequivalog
HMM Length130
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0006825: copper ion transport biological_process
GO:0016564: transcription repressor activity molecular_function
AuthorHaft DH
Entry DateNov 21 2005 1:22PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family includes metal-fist type transcriptional repressors of copper transport systems such as copYZAB of Enterococcus hirae and tcrYAZB (transferble copper resistance) of an Enterocuccus faecium plasmid. High levels of copper can displace zinc and prevent binding by the repressor, activating efflux by copper resistance transporters. The most closely related proteins excluded by this model are antibiotic resistance regulators including the methicillin resistance regulatory protein MecI.
ReferencesDR PFAM; PF03965; Pencillinase_R; transcriptional regulator, BlaI/MecI/CopY family RM 16151212 RT The tcrB gene is part of the tcrYAZB operon conferring copper resistance in Enterococcus faecium and Enterococcus faecalis. RA Hasman H. RL Microbiology. 2005 Sep;151(Pt 9):3019-25.
Genome PropertyGenProp0477: copper resistance system: CopZA (HMM)