HMM Summary Page: TIGR02696

Functionguanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase
Gene SymbolgpsI
Trusted Cutoff1106.75
Domain Trusted Cutoff1106.75
Noise Cutoff892.55
Domain Noise Cutoff892.55
Isology Typeexception
EC Number2.7.-.-
HMM Length720
AuthorHaft DH
Entry DateNov 17 2005 3:42PM
Last ModifiedFeb 14 2011 3:27PM
CommentSohlberg, et al. [1] present characterization of two proteins from Streptomyces coelicolor. The protein in this family was shown to have poly(A) polymerase activity and may be responsible for polyadenylating RNA in this species. Reference 2 showed that a nearly identical plasmid-encoded protein from Streptomyces antibioticus is a bifunctional enzyme that acts also as a guanosine pentaphosphate synthetase.
ReferencesRN [1] RM 14645289 RT The Streptomyces coelicolor polynucleotide phosphorylase homologue, and not the putative poly(A) polymerase, can polyadenylate RNA. RA Sohlberg B, Huang J, Cohen SN. RL J Bacteriol. 2003 Dec;185(24):7273-8. RN [2] RM PMID:8763958 RT Guanosine pentaphosphate synthetase from Streptomyces antibioticus is also a polynucleotide phosphorylase. RA Jones GH, Bibb MJ RL J Bacteriol. 1996 Jul;178(14):4281-8. DR HAMAP; MF_01595; 43 of 528