HMM Summary Page: TIGR02692

FunctionCCA tRNA nucleotidyltransferase
Trusted Cutoff438.80
Domain Trusted Cutoff438.80
Noise Cutoff402.00
Domain Noise Cutoff402.00
Isology Typeequivalog
EC Number2.7.7.72
HMM Length466
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
AuthorHaft DH
Entry DateNov 16 2005 1:32PM
Last ModifiedJun 7 2011 2:51PM
CommentThe enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family PF01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase.
ReferencesDR PFAM; PF01743; PolyA_pol RN [1] RM 14645289 RT The Streptomyces coelicolor polynucleotide phosphorylase homologue, and not the putative poly(A) polymerase, can polyadenylate RNA. RA Sohlberg B, Huang J, Cohen SN. RL J Bacteriol. 2003 Dec;185(24):7273-8.