HMM Summary Page: TIGR02683

Functionputative addiction module killer protein
Trusted Cutoff62.85
Domain Trusted Cutoff62.85
Noise Cutoff36.30
Domain Noise Cutoff36.30
Isology Typehypoth_equivalog
HMM Length95
Gene Ontology TermGO:0008219: cell death biological_process
AuthorHaft DH
Entry DateNov 9 2005 1:50PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family PF01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.
ReferencesDR PFAM; PF01381; HTH_3; Helix-turn-helix
Genome PropertyGenProp0471: uncharacterized gene pair TIGR02683/TIGR02684 (HMM)