HMM Summary Page: TIGR02669

FunctionSpoIID/LytB domain
Trusted Cutoff83.30
Domain Trusted Cutoff83.30
Noise Cutoff37.35
Domain Noise Cutoff37.35
Isology Typedomain
HMM Length270
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0005575: cellular_component cellular_component
GO:0008150: biological_process biological_process
AuthorHaft DH
Entry DateSep 27 2005 11:53AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a domain found typically in two or three proteins per genome in Cyanobacteria and Firmicutes, and sporadically in other genomes. One member is SpoIID of Bacillus subtilis. Another in B. subtilis is the C-terminal half of LytB, encoded immediately upstream of an amidase, the autolysin LytC, to which its N-terminus is homologous. Gene neighborhoods are not well conserved for members of this family, as many, such as SpoIID, are monocistronic. One early modelling-based study suggests a DNA-binding role for SpoIID, but the function of this domain is unknown.
ReferencesRN [1] RM 1357079 RT Sequencing and analysis of the Bacillus subtilis lytRABC divergon: a regulatory unit encompassing the structural genes of the N-acetylmuramoyl-L-alanine amidase and its modifier. RA J Gen Microbiol. 1992 Sep;138(9):1949-61. RN [2] RM 3129534 RT The possible DNA-binding nature of the regulatory proteins, encoded by spoIID and gerE, involved in the sporulation of Bacillus subtilis. RA Holland SK, Cutting S, Mandelstam J. RL J Gen Microbiol. 1987 Sep;133(9):2381-91.