HMM Summary Page: TIGR02665

Functionmolybdenum cofactor guanylyltransferase
Gene SymbolmobA
Trusted Cutoff151.85
Domain Trusted Cutoff151.85
Noise Cutoff125.95
Domain Noise Cutoff125.95
Isology Typeequivalog
EC Number2.7.7.77
HMM Length186
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMolybdopterin
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0005525: GTP binding molecular_function
GO:0006777: Mo-molybdopterin cofactor biosynthetic process biological_process
AuthorHaft DH
Entry DateSep 16 2005 9:09AM
Last ModifiedFeb 14 2011 3:27PM
CommentIn many molybdopterin-containing enzymes, including nitrate reductase and dimethylsulfoxide reductase, the cofactor is molybdopterin-guanine dinucleotide. The family described here contains MobA, molybdenum cofactor guanylyltransferase, from the Proteobacteria only. MobA can reconstitute molybdopterin-guanine dinucleotide biosynthesis without the product of the neighboring gene MobB. The probable MobA proteins of other lineages differ sufficiently that they are not included in scope of this family.
ReferencesDR EXPERIMENTAL; SP|P32173; Escherichia coli DR EXPERIMENTAL; SP|P95645; Rhodobacter sphaeroides RN [1] RM 12719427 RT Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA. RA Guse A, Stevenson CE, Kuper J, Buchanan G, Schwarz G, Giordano G, Magalon A, Mendel RR, Lawson DM, Palmer T. RL J Biol Chem. 2003 Jul 11;278(28):25302-7. RN [2] RT Characterisation of the mob locus of Rhodobacter sphaeroides WS8: mobA is the only gene required for molybdopterin guanine dinucleotide synthesis. RA Buchanan G, Kuper J, Mendel RR, Schwarz G, Palmer T. RL Arch Microbiol. 2001 Jul;176(1-2):62-8. DR HAMAP; MF_00316; 80 of 151
Genome PropertyGenProp0466: molybdopterin biosynthesis (HMM)