| Accession | TIGR02665 |
| Name | molyb_mobA |
| Function | molybdenum cofactor guanylyltransferase |
| Gene Symbol | mobA |
| Trusted Cutoff | 151.85 |
| Domain Trusted Cutoff | 151.85 |
| Noise Cutoff | 125.95 |
| Domain Noise Cutoff | 125.95 |
| Isology Type | equivalog |
| EC Number | 2.7.7.77 |
| HMM Length | 186 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Molybdopterin |
| Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| | GO:0005525: GTP binding molecular_function |
| | GO:0006777: Mo-molybdopterin cofactor biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Sep 16 2005 9:09AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | In many molybdopterin-containing enzymes, including nitrate reductase and dimethylsulfoxide reductase, the cofactor is molybdopterin-guanine dinucleotide. The family described here contains MobA, molybdenum cofactor guanylyltransferase, from the Proteobacteria only. MobA can reconstitute molybdopterin-guanine dinucleotide biosynthesis without the product of the neighboring gene MobB. The probable MobA proteins of other lineages differ sufficiently that they are not included in scope of this family. |
| References | DR EXPERIMENTAL; SP|P32173; Escherichia coli
DR EXPERIMENTAL; SP|P95645; Rhodobacter sphaeroides
RN [1]
RM 12719427
RT Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA.
RA Guse A, Stevenson CE, Kuper J, Buchanan G, Schwarz G, Giordano G, Magalon A, Mendel RR, Lawson DM, Palmer T.
RL J Biol Chem. 2003 Jul 11;278(28):25302-7.
RN [2]
RT Characterisation of the mob locus of Rhodobacter sphaeroides WS8: mobA is the only gene required for molybdopterin guanine dinucleotide synthesis.
RA Buchanan G, Kuper J, Mendel RR, Schwarz G, Palmer T.
RL Arch Microbiol. 2001 Jul;176(1-2):62-8.
DR HAMAP; MF_00316; 80 of 151 |
| Genome Property | GenProp0466: molybdopterin biosynthesis (HMM) |
