HMM Summary Page: TIGR02661

Functionmethylamine dehydrogenase accessory protein MauD
Gene SymbolmauD
Trusted Cutoff188.60
Domain Trusted Cutoff188.60
Noise Cutoff52.55
Domain Noise Cutoff52.55
Isology Typeequivalog
HMM Length189
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
AuthorHaft DH
Entry DateSep 9 2005 1:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein, MauD, appears critical to proper formation of the small subunit of methylamine dehydrogenase, which has both an unusual tryptophan tryptophylquinone cofactor and multiple disulfide bonds. MauD shares sequence similarity, including a CPxC motif, with a number of thiol:disulfide interchange proteins. In MauD mutants, the small subunit apparently does not form properly and is rapidly degraded.
ReferencesRN [1] RM 9403107 RT MauE and MauD proteins are essential in methylamine metabolism of Paracoccus denitrificans. RA van der Palen CJ, Reijnders WN, de Vries S, Duine JA, van Spanning RJ. RL Antonie Van Leeuwenhoek. 1997 Oct;72(3):219-28.
Genome PropertyGenProp0860: tryptophan tryptophylquinone modification of methylamine dehydrogenase (HMM)