HMM Summary Page: TIGR02650

Functionribonuclease Z, Thermotoga type
Gene Symbolrnz
Trusted Cutoff507.05
Domain Trusted Cutoff507.05
Noise Cutoff92.35
Domain Noise Cutoff92.35
Isology Typeequivalog
EC Number3.1.26.11
HMM Length277
Mainrole CategoryTranscription
Subrole CategoryRNA processing
AuthorHaft DH
Entry DateAug 30 2005 4:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are ribonuclease Z as found in the genus Thermotoga, where the enzyme cleaves after the CCA, in contrast to the activities characterized for other enzymes also designated ribonuclease Z. In other systems, cleavage occurs 5-prime to the location of the CCA sequence, and CCA is added subsequently. A species may lack ribonuclease Z if all tRNA genes encode the CCA sequence, or if the CCA is exposed by exonuclease activity rather than endonuclease activity. Note that members of this sequence family differ considerably from the majority of RNase Z sequences.
ReferencesDR PFAM; PF00753; metallo-beta-lactamase superfamily RN [1] RM 15701599 RT Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima. RA Ishii R, Minagawa A, Takaku H, Takagi M, Nashimoto M, Yokoyama S. RL J Biol Chem. 2005 Apr 8;280(14):14138-44.