HMM Summary Page: TIGR02625

FunctionL-rhamnose mutarotase
Gene SymbolrhaM
Trusted Cutoff99.60
Domain Trusted Cutoff99.60
Noise Cutoff84.70
Domain Noise Cutoff84.70
Isology Typeequivalog
EC Number5.1.3.-
HMM Length102
Mainrole CategoryEnergy metabolism
Subrole CategorySugars
Gene Ontology TermGO:0016857: racemase and epimerase activity, acting on carbohydrates and derivatives molecular_function
GO:0019301: rhamnose catabolic process biological_process
AuthorHaft DH
Entry DateJul 25 2005 3:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are rhamnose mutarotase from Escherichia coli, previously designated YiiL as an uncharacterized protein, and close homologs also associated with rhamnose dissimilation operons in other bacterial genomes. Mutarotase is a term for an epimerase that changes optical activity. This enzyme was shown experimentally to interconvert alpha and beta stereoisomers of the pyranose form of L-rhamnose [1]. The crystal structure of this small (104 amino acid) protein shows a locally asymmetric dimer with active site residues of His, Tyr, and Trp [2].
ReferencesDR PFAM; PF05336; Protein of unknown function (DUF718) RN [1] RM 15060078 RT NMR application probes a novel and ubiquitous family of enzymes that alter monosaccharide configuration. RA Ryu KS, Kim C, Kim I, Yoo S, Choi BS, Park C. RL J Biol Chem. 2004 Jun 11;279(24):25544-8 RN [2] RM 15876375 RT Structural insights into the monosaccharide specificity of Escherichia coli rhamnose mutarotase. RA Ryu KS, Kim JI, Cho SJ, Park D, Park C, Cheong HK, Lee JO, Choi BS. RL J Mol Biol. 2005 May 27;349(1):153-62. DR HAMAP; MF_01663; 66 of 72
Genome PropertyGenProp0457: rhamnose catabolism (HMM)