| Accession | TIGR02625 |
| Name | YiiL_rotase |
| Function | L-rhamnose mutarotase |
| Gene Symbol | rhaM |
| Trusted Cutoff | 99.60 |
| Domain Trusted Cutoff | 99.60 |
| Noise Cutoff | 84.70 |
| Domain Noise Cutoff | 84.70 |
| Isology Type | equivalog |
| EC Number | 5.1.3.- |
| HMM Length | 102 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Sugars |
| Gene Ontology Term | GO:0016857: racemase and epimerase activity, acting on carbohydrates and derivatives molecular_function |
| | GO:0019301: rhamnose catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Jul 25 2005 3:33PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are rhamnose mutarotase from Escherichia coli, previously designated YiiL as an uncharacterized protein, and close homologs also associated with rhamnose dissimilation operons in other bacterial genomes. Mutarotase is a term for an epimerase that changes optical activity. This enzyme was shown experimentally to interconvert alpha and beta stereoisomers of the pyranose form of L-rhamnose [1]. The crystal structure of this small (104 amino acid) protein shows a locally asymmetric dimer with active site residues of His, Tyr, and Trp [2]. |
| References | DR PFAM; PF05336; Protein of unknown function (DUF718)
RN [1]
RM 15060078
RT NMR application probes a novel and ubiquitous family of enzymes that alter monosaccharide configuration.
RA Ryu KS, Kim C, Kim I, Yoo S, Choi BS, Park C.
RL J Biol Chem. 2004 Jun 11;279(24):25544-8
RN [2]
RM 15876375
RT Structural insights into the monosaccharide specificity of Escherichia coli rhamnose mutarotase.
RA Ryu KS, Kim JI, Cho SJ, Park D, Park C, Cheong HK, Lee JO, Choi BS.
RL J Mol Biol. 2005 May 27;349(1):153-62.
DR HAMAP; MF_01663; 66 of 72 |
| Genome Property | GenProp0457: rhamnose catabolism (HMM) |
