HMM Summary Page: TIGR02622

FunctionCDP-glucose 4,6-dehydratase
Gene SymbolrfbG
Trusted Cutoff278.45
Domain Trusted Cutoff278.45
Noise Cutoff148.25
Domain Noise Cutoff148.25
Isology Typeequivalog
EC Number4.2.1.45
HMM Length352
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0009243: O antigen biosynthetic process biological_process
GO:0047733: CDP-glucose 4,6-dehydratase activity molecular_function
AuthorHaft DH
Entry DateJul 18 2005 11:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are CDP-glucose 4,6-dehydratase from a variety of Gram-negative and Gram-positive bacteria. Members typically are encoded next to a gene that encodes a glucose-1-phosphate cytidylyltransferase, which produces the substrate, CDP-D-glucose, used by this enzyme to produce CDP-4-keto-6-deoxyglucose.
ReferencesRN [1] RM 15023057 RT Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis. RA Vogan EM, Bellamacina C, He X, Liu HW, Ringe D, Petsko GA. RL Biochemistry. 2004 Mar 23;43(11):3057-67. RN [2] RM 9367902 RT Identification and mutational analysis of rfbG, the gene encoding CDP-D-glucose-4,6-dehydratase, isolated from free living soil bacterium Azotobacter vinelandii. RA Gavini N, Hausman BS, Pulakat L, Schreiner RP, Williamson JA. RL Biochem Biophys Res Commun. 1997 Nov 7;240(1):153-61.