| Accession | TIGR02622 |
| Name | CDP_4_6_dhtase |
| Function | CDP-glucose 4,6-dehydratase |
| Gene Symbol | rfbG |
| Trusted Cutoff | 278.45 |
| Domain Trusted Cutoff | 278.45 |
| Noise Cutoff | 148.25 |
| Domain Noise Cutoff | 148.25 |
| Isology Type | equivalog |
| EC Number | 4.2.1.45 |
| HMM Length | 352 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0009243: O antigen biosynthetic process biological_process |
| | GO:0047733: CDP-glucose 4,6-dehydratase activity molecular_function |
| Author | Haft DH |
| Entry Date | Jul 18 2005 11:03PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are CDP-glucose 4,6-dehydratase from a variety of Gram-negative and Gram-positive bacteria. Members typically are encoded next to a gene that encodes a glucose-1-phosphate cytidylyltransferase, which produces the substrate, CDP-D-glucose, used by this enzyme to produce CDP-4-keto-6-deoxyglucose. |
| References | RN [1]
RM 15023057
RT Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis.
RA Vogan EM, Bellamacina C, He X, Liu HW, Ringe D, Petsko GA.
RL Biochemistry. 2004 Mar 23;43(11):3057-67.
RN [2]
RM 9367902
RT Identification and mutational analysis of rfbG, the gene encoding CDP-D-glucose-4,6-dehydratase, isolated from free living soil bacterium Azotobacter vinelandii.
RA Gavini N, Hausman BS, Pulakat L, Schreiner RP, Williamson JA.
RL Biochem Biophys Res Commun. 1997 Nov 7;240(1):153-61. |
