HMM Summary Page: TIGR02616

Functiontryptophanase leader peptide
Gene SymboltnaC
Trusted Cutoff23.55
Domain Trusted Cutoff23.55
Noise Cutoff23.35
Domain Noise Cutoff23.35
Isology Typeequivalog
HMM Length22
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0006569: tryptophan catabolic process biological_process
GO:0031554: regulation of transcription termination, DNA-dependent biological_process
GO:0031556: transcriptional attenuation by ribosome biological_process
AuthorHaft DH
Entry DateJul 8 2005 12:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the apparent leader peptides of tryptophanase operons in Esherichia coli, Vibrio cholerae, Photobacterium profundum, Haemophilus influenzae type b, and related species. All members of the seed alignment are examples ORFs upstream of tryptophanase, with a start codon, a conserved single Trp residue, and several other conserved residues. It is suggested (Konan KV and Yanofsky C) that the nascent peptide interacts with the ribosome once (if) the ribosome reaches the stop codon. Note that this model describes a much broader set (and shorter protein region) than Pfam model PF08053.
ReferencesRN [1] RM 9045840 RT Regulation of the Escherichia coli tna operon: nascent leader peptide control at the tnaC stop codon. RA Konan KV, Yanofsky C. RL J Bacteriol. 1997 Mar;179(5):1774-9. DR PFAM; PF08053; Tryptophanese operon leader peptide
Genome PropertyGenProp0456: attenuation system: tryptophanase (HMM)