| Accession | TIGR02616 |
| Name | tnaC_leader |
| Function | tryptophanase leader peptide |
| Gene Symbol | tnaC |
| Trusted Cutoff | 23.55 |
| Domain Trusted Cutoff | 23.55 |
| Noise Cutoff | 23.35 |
| Domain Noise Cutoff | 23.35 |
| Isology Type | equivalog |
| HMM Length | 22 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Amino acids and amines |
| Gene Ontology Term | GO:0006569: tryptophan catabolic process biological_process |
| | GO:0031554: regulation of transcription termination, DNA-dependent biological_process |
| | GO:0031556: transcriptional attenuation by ribosome biological_process |
| Author | Haft DH |
| Entry Date | Jul 8 2005 12:41PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are the apparent leader peptides of tryptophanase operons in Esherichia coli, Vibrio cholerae, Photobacterium profundum, Haemophilus influenzae type b, and related species. All members of the seed alignment are examples ORFs upstream of tryptophanase, with a start codon, a conserved single Trp residue, and several other conserved residues. It is suggested (Konan KV and Yanofsky C) that the nascent peptide interacts with the ribosome once (if) the ribosome reaches the stop codon. Note that this model describes a much broader set (and shorter protein region) than Pfam model PF08053. |
| References | RN [1]
RM 9045840
RT Regulation of the Escherichia coli tna operon: nascent leader peptide control at the tnaC stop codon.
RA Konan KV, Yanofsky C.
RL J Bacteriol. 1997 Mar;179(5):1774-9.
DR PFAM; PF08053; Tryptophanese operon leader peptide |
| Genome Property | GenProp0456: attenuation system: tryptophanase (HMM) |
