HMM Summary Page: TIGR02614

Functioncell division protein FtsW
Gene SymbolftsW
Trusted Cutoff337.50
Domain Trusted Cutoff337.50
Noise Cutoff314.70
Domain Noise Cutoff314.70
Isology Typeequivalog
HMM Length357
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0009252: peptidoglycan biosynthetic process biological_process
GO:0016021: integral to membrane cellular_component
GO:0051301: cell division biological_process
AuthorHaft DH
Entry DateJul 1 2005 10:19AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of FtsW, an integral membrane protein with ten transmembrane segments [1]. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site.
ReferencesRN [1] RM 15576787 RT Functional analysis of the cell division protein FtsW of Escherichia coli. RA Pastoret S, Fraipont C, den Blaauwen T, Wolf B, Aarsman ME, Piette A, Thomas A, Brasseur R, Nguyen-Disteche M. RL J Bacteriol. 2004 Dec;186(24):8370-9.