HMM Summary Page: TIGR02607

Functionaddiction module antidote protein, HigA family
Gene SymbolhigA
Trusted Cutoff47.70
Domain Trusted Cutoff47.70
Noise Cutoff40.00
Domain Noise Cutoff40.00
Isology Typeequivalog
HMM Length81
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003677: DNA binding molecular_function
AuthorHaft DH
Entry DateJun 15 2005 12:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by Pfam model PF01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair.
ReferencesDR PFAM; PF01381; HTH_3; Helix-turn-helix DR COGS; COG3093; Plasmid maintenance system antidote protein RN [1] RM 11322821 RT Specific protein-DNA and protein-protein interaction in the hig gene system, a plasmid-borne proteic killer gene system of plasmid Rts1. RA Tian QB, Ohnishi M, Murata T, Nakayama K, Terawaki Y, Hayashi T. RL Plasmid. 2001 Mar;45(2):63-74.
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)
GenProp0322: addiction module, hig class (HMM)