HMM Summary Page: TIGR02606

Functionputative addiction module antidote protein, CC2985 family
Trusted Cutoff46.20
Domain Trusted Cutoff46.20
Noise Cutoff33.35
Domain Noise Cutoff33.35
Isology Typehypoth_equivalog
HMM Length70
Mainrole CategoryCellular processes
Subrole CategoryOther
Gene Ontology TermGO:0051983: regulation of chromosome segregation biological_process
AuthorHaft DH
Entry DateJun 15 2005 9:43AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis bacterial protein family has a very similar seed alignment to that of Pfam model PF03693 but is a more stringent model with higher cutoff scores. Proteins that score above the trusted cutoff to this model almost invariably are found adjacent to a ParE family protein (PF05016), where ParE is the killing partner of an addiction module for plasmid stabilization. Members of this family, therefore, are putative addiction module antidote proteins. Some are encoded on plasmids or in prophage regions, but others appear chromosomal. A genome may contain several identical copies, such as the four in Magnetococcus sp. MC-1. This family is named for one member, CC2985 of Caulobacter crescentus CB15.
ReferencesDR PFAM; PF03693
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)
GenProp0323: addiction module, ParE class (HMM)