HMM Summary Page: TIGR02605

Functionputative regulatory protein, FmdB family
Trusted Cutoff31.30
Domain Trusted Cutoff31.30
Noise Cutoff29.40
Domain Noise Cutoff29.40
Isology Typesubfamily_domain
HMM Length52
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
AuthorHaft DH
Entry DateJun 13 2005 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, PMID:8841393 ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors.