HMM Summary Page: TIGR02568

Functiontype III secretion regulator YopN/LcrE/InvE/MxiC
Trusted Cutoff89.50
Domain Trusted Cutoff89.50
Noise Cutoff51.60
Domain Noise Cutoff51.60
Isology Typeequivalog
HMM Length241
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0009986: cell surface cellular_component
GO:0030254: protein secretion by the type III secretion system biological_process
GO:0050709: negative regulation of protein secretion biological_process
AuthorSelengut J
Entry DateMay 2 2005 9:30AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein is found in type III secretion operons and, in Yersinia is localized to the cell surface and is involved in the Low-Calicium Response (LCR), possibly by sensing the calcium concentration [1]. In Salmonella, the gene is known as InvE and is believed to perform an essential role in the secretion process and interacts with the proteins SipBCD and SicA [2].//Altered name to reflect regulatory role. Added GO and role IDs . Negative regulation of type III secretion in Y pestis is mediated in part by a multiprotein complex that has been proposed to act as a physical impediment to type III secretion by blocking the entrance to the secretion apparatus prior to contact with mammalian cells. This complex is composed of YopN, its heterodimeric secretion chaperone SycN-YscB, and TyeA. PMID: 15701523[SS 6/3/05]
ReferencesRN [1] RM PMID: 1857212 RT The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis. RA Forsberg A, Viitanen AM, Skurnik M, Wolf-Watz H. RL Mol Microbiol. 1991 Apr;5(4):977-86. RN [2] RM PMID: 12169593
Genome PropertyGenProp0052: type III secretion (HMM)