HMM Summary Page: TIGR02563

FunctionCRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST
Gene Symbolcas6f
Trusted Cutoff36.25
Domain Trusted Cutoff36.25
Noise Cutoff29.30
Domain Noise Cutoff29.30
Isology Typeequivalog
EC Number3.1.-.-
HMM Length184
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateApr 25 2005 12:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentCRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. This family is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.
ReferencesDR URL DR URL RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [2] RM PMID:22522703 RT Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA. RA Haurwitz RE, Sternberg SH, Doudna JA RL EMBO J. 2012 Apr 20;31(12):2824-32.
Genome PropertyGenProp0310: CRISPR system, I-F/Ypest subtype (HMM)
GenProp0021: CRISPR region (HMM)