HMM Summary Page: TIGR02554

Functiontype III secretion apparatus protein PrgH/EprH
Gene SymboleprH
Trusted Cutoff188.60
Domain Trusted Cutoff188.60
Noise Cutoff166.70
Domain Noise Cutoff166.70
Isology Typeequivalog
HMM Length389
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0030254: protein secretion by the type III secretion system biological_process
GO:0030257: type III protein secretion system complex cellular_component
AuthorSelengut J
Entry DateApr 19 2005 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn Samonella, this gene is part of a four-gene operon PrgHIJK and in general is found in type III secretion operons. PrgH has been shown to be required for secretion [1], as well as being a structural component of the needle complex [2].
ReferencesRN [1] RM PMID: 7476203 RT PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion. RA Pegues DA, Hantman MJ, Behlau I, Miller SI. RL Mol Microbiol. 1995 Jul;17(1):169-81. RN [2] RM PMID: 15528446 RT Structural insights into the assembly of the type III secretion needle complex. RA Marlovits TC, Kubori T, Sukhan A, Thomas DR, Galan JE, Unger VM. RL Science. 2004 Nov 5;306(5698):1040-2.
Genome PropertyGenProp0052: type III secretion (HMM)