HMM Summary Page: TIGR02551

Functiontype III secretion apparatus protein, YscQ/HrcQ family
Gene SymbolepaO
Trusted Cutoff100.80
Domain Trusted Cutoff100.80
Noise Cutoff79.00
Domain Noise Cutoff79.00
Isology Typeequivalog
HMM Length300
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0009405: pathogenesis biological_process
GO:0030254: protein secretion by the type III secretion system biological_process
GO:0030257: type III protein secretion system complex cellular_component
AuthorSelengut J
Entry DateApr 18 2005 1:18PM
Last ModifiedFeb 14 2011 3:27PM
CommentGenes in this family are found in type III secretion operons. The gene (YscQ) in Yersinia is essential for YOPs secretion [1], while SpaO in Shigella is involved in the Surface Presentation of Antigens apparatus found on the virulence plasmid [2], and HrcQ is involved in the Harpin secretory system in organisms like Pseudomonas syringae [3].
ReferencesRN [1] RM PMID: 8169210 RT The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium. RA Bergman T, Erickson K, Galyov E, Persson C, Wolf-Watz H. RL J Bacteriol. 1994 May;176(9):2619-26. RN [2] RM PMID: 8404849 RT Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri. RA Groisman EA, Ochman H. RL EMBO J. 1993 Oct;12(10):3779-87. RN [3] RM PMID: 9721292 RT Negative regulation of hrp genes in Pseudomonas syringae by HrpV. RA Preston G, Deng WL, Huang HC, Collmer A. RL J Bacteriol. 1998 Sep;180(17):4532-7.
Genome PropertyGenProp0052: type III secretion (HMM)