HMM Summary Page: TIGR02539

FunctionO-phospho-L-seryl-tRNA:Cys-tRNA synthase
Gene SymbolpscS
Trusted Cutoff365.25
Domain Trusted Cutoff365.25
Noise Cutoff214.40
Domain Noise Cutoff214.40
Isology Typeequivalog
EC Number2.5.1.73
HMM Length370
AuthorHaft DH
Entry DateApr 5 2005 11:58AM
Last ModifiedJan 9 2012 11:52AM
CommentAminoacylation of tRNA(Cys) with Cys, and cysteine biosynthesis in the process, happens in Methanocaldococcus jannaschii and several other archaea by misacylation of tRNA(Cys) with O-phosphoserine (Sep), followed by modification of the phosphoserine to cysteine. In some species, direct tRNA-cys aminoacylation also occurs but this pathway is required for Cys biosynthesis. Members of this protein catalyze the second step in this two step pathway, using pyridoxal phosphate and a sulfur donor to synthesize Cys from Sep while attached to the tRNA.
ReferencesRN [1] RM 15790858 RT RNA-dependent cysteine biosynthesis in archaea. RA Sauerwald A, Zhu W, Major TA, Roy H, Palioura S, Jahn D, Whitman WB, Yates JR 3rd, Ibba M, Soll D. RL Science. 2005 Mar 25;307(5717):1969-72. DR HAMAP; MF_01675; 25 of 26
Genome PropertyGenProp0304: cysteine biosynthesis, tRNA-dependent (HMM)