HMM Summary Page: TIGR02535

Functionproposed homoserine kinase
Trusted Cutoff446.30
Domain Trusted Cutoff446.30
Noise Cutoff387.10
Domain Noise Cutoff387.10
Isology Typehypoth_equivalog
HMM Length397
AuthorSelengut J
Entry DateMar 21 2005 4:43PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe genes in this family are largely adjacent to genes involved in the biosynthesis of threonine (aspartate kinase, homoserine dehydrogenase and threonine synthase) in genomes which are lacking any other known homoserine kinase, and in which the presence of a homoserine kinase would indicate a complete pathway for the biosynthesis of threonine. These genes are a member of the (now subfamily, formerly equivalog) TIGR00306 model describing the archaeal form of 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. All of these are members of a superfamily (PF01676) of metalloenzyme also including phosphopentomutase alkaline phosphatases and sulfatases. The proposal that this family encodes a kinase is based on analogy to phosphomutases which are intramolecular phosphotransferases. A mutase active site could evolve to bring together homoserine and a phosphate donor such as phosphoenolpyruvate resulting in a kinase activity.
ReferencesCC DR HAMAP; MF_01402; 8 of 47
Genome PropertyGenProp0159: threonine biosynthesis from aspartate semialdehyde (HMM)