HMM Summary Page: TIGR02527

FunctionDot/Icm secretion system protein IcmQ
Gene SymbolicmQ
Trusted Cutoff99.10
Domain Trusted Cutoff99.10
Noise Cutoff98.85
Domain Noise Cutoff98.85
Isology Typeequivalog
HMM Length179
AuthorHaft DH
Entry DateMar 15 2005 1:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the IcmQ component of Dot/Icm secretion systems, as found in obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii. While this system resembles type IV secretion systems and has been called a form of type IV, the literature now seems to favor calling this the Dot/Icm system. This protein was shown to be essential for translocation (PMID:15661013).
ReferencesRM 15661013 RT The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation. RA Ninio S, Zuckman-Cholon DM, Cambronne ED, Roy CR. RL Mol Microbiol. 2005 Feb;55(3):912-26.