HMM Summary Page: TIGR02524

FunctionDot/Icm secretion system ATPase DotB
Gene SymboldotB
Trusted Cutoff463.30
Domain Trusted Cutoff463.30
Noise Cutoff230.40
Domain Noise Cutoff230.40
Isology Typeequivalog
HMM Length358
AuthorHaft DH
Entry DateMar 14 2005 5:21PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the DotB component of Dot/Icm secretion systems, as found in obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii. While this system resembles type IV secretion systems and has been called a form of type IV, the liturature now seems to favor calling this the Dot/Icm system. This family is most closely related to TraJ proteins of plasmid transfer, rather than to proteins of other type IV secretion systems.
ReferencesRM 15661013 RT The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation. RA Ninio S, Zuckman-Cholon DM, Cambronne ED, Roy CR. RL Mol Microbiol. 2005 Feb;55(3):912-26.