HMM Summary Page: TIGR02521

Functiontype IV pilus biogenesis/stability protein PilW
Gene SymbolpilF
Trusted Cutoff154.00
Domain Trusted Cutoff154.00
Noise Cutoff97.25
Domain Noise Cutoff97.25
Isology Typeequivalog
HMM Length234
AuthorHaft DH
Entry DateMar 10 2005 5:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are designated PilF in ref [1] (PMID:8973346) and PilW in ref [2] (PMID:15612916). This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.
ReferencesDR PFAM; PF00515; TPR Domain RN [1] RM 8973346 RT Identification of a gene, pilF, required for type 4 fimbrial biogenesis and twitching motility in Pseudomonas aeruginosa. RA Watson AA, Alm RA, Mattick JS. RL Gene. 1996 Nov 21;180(1-2):49-56. RN [2] RM 15612916 RT Type IV pilus biogenesis in Neisseria meningitidis: PilW is involved in a step occurring after pilus assembly, essential for fibre stability and function. RA Carbonnelle E, Helaine S, Prouvensier L, Nassif X, Pelicic V. RL Mol Microbiol. 2005 Jan;55(1):54-64.