HMM Summary Page: TIGR02515

Functiontype IV pilus secretin PilQ
Gene SymbolpilQ
Trusted Cutoff284.35
Domain Trusted Cutoff284.35
Noise Cutoff202.40
Domain Noise Cutoff202.40
Isology Typesubfamily
HMM Length428
Mainrole CategoryCell envelope
Subrole CategorySurface structures
Gene Ontology TermGO:0009297: pilus assembly biological_process
GO:0009306: protein secretion biological_process
AuthorHaft DH
Entry DateMar 9 2005 4:16PM
Last ModifiedFeb 14 2011 3:27PM
CommentA number of proteins homologous to PilQ are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). Members of this family include PilQ itself, which is a component of the type IV pilus structure, from a number of species. In Haemophilus influenzae, the member of this family is associated with competence for transformation with exogenous DNA rather than with formation of a type IV pilus; the surface structure required for competence may be considered an unusual, incomplete type IV pilus structure.
ReferencesDR PFAM; PF07660; STN DR PFAM; PF03958; Secretin_N DR PFAM; PF00263; Secretin_C RN [1] RM 14729699 RT A mutant form of the Neisseria gonorrhoeae pilus secretin protein PilQ allows increased entry of heme and antimicrobial compounds. RA Chen CJ, Tobiason DM, Thomas CE, Shafer WM, Seifert HS, Sparling PF. RL J Bacteriol. 2004 Feb;186(3):730-9.