HMM Summary Page: TIGR02512

Function[FeFe] hydrogenase, group A
Trusted Cutoff405.95
Domain Trusted Cutoff405.95
Noise Cutoff300.65
Domain Noise Cutoff300.65
Isology Typesubfamily
EC Number1.12.-.-
HMM Length375
AuthorHaft DH
Entry DateMar 8 2005 4:26PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes iron-only hydrogenases of anaerobic and microaerophilic bacteria and protozoa. This model is narrower, and covers a longer stretch of sequence, than Pfam model PF02906. This family represents a division among families that belong to PF02906, which also includes proteins such as nuclear prelamin A recognition factor in animals. Note that this family shows some heterogeneity in terms of periplasmic, cytosolic, or hydrogenosome location, NAD or NADP dependence, and overal protein protein length.
ReferencesDR PFAM; PF02906; Fe_hyd_lg_C RN [1] RM 11070057 RT Iron hydrogenases and the evolution of anaerobic eukaryotes. RA Horner DS, Foster PG, Embley TM. RL Mol Biol Evol. 2000 Nov;17(11):1695-709. RN [2] RM PMID:20395274 RT The surprising diversity of clostridial hydrogenases: a comparative genomic perspective. RA Calusinska M, Happe T, Joris B, Wilmotte A RL Microbiology. 2010 Jun;156(Pt 6):1575-88.
Genome PropertyGenProp0914: hydrogenase, [FeFe]-dependent (HMM)