HMM Summary Page: TIGR02509

Functiontype III secretion effector, YopR family
Trusted Cutoff114.00
Domain Trusted Cutoff114.00
Noise Cutoff55.25
Domain Noise Cutoff55.25
Isology Typeequivalog
HMM Length131
Mainrole CategoryCellular processes
Subrole CategoryPathogenesis
AuthorHaft DH
Entry DateMar 7 2005 5:27PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are type III secretion system effectors, named differently in different species and designated YopR (Yersinia outer protein R), encoded by the YscH (Yersinia secretion H) gene. This Yops protein is unusual in that it is released to extracellularly rather than injected directly into the target cell as are most Yops.
ReferencesRN [1] RM 10209737 RT Type III machines of pathogenic yersiniae secrete virulence factors into the extracellular milieu. RA Lee VT, Schneewind O. RL Mol Microbiol. 1999 Mar;31(6):1619-29. RN [2] RM 8709853 RT Mutational analysis of the Yersinia enterocolitica virC operon: characterization of yscE, F, G, I, J, K required for Yop secretion and yscH encoding YopR. RA Allaoui A, Schulte R, Cornelis GR. RL Mol Microbiol. 1995 Oct;18(2):343-55.
Genome PropertyGenProp0052: type III secretion (HMM)