| Accession | TIGR02505 |
| Name | RTPR |
| Function | ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent |
| Gene Symbol | nrdJ |
| Trusted Cutoff | 340.05 |
| Domain Trusted Cutoff | 340.05 |
| Noise Cutoff | 154.15 |
| Domain Noise Cutoff | 154.15 |
| Isology Type | equivalog |
| EC Number | 1.17.4.2 |
| HMM Length | 724 |
| Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
| Subrole Category | 2'-Deoxyribonucleotide metabolism |
| Gene Ontology Term | GO:0016960: class II ribonucleotide reductase activity molecular_function |
| Author | Selengut J |
| Entry Date | Mar 7 2005 1:53PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (RNR) related to the characterized species from Lactococcus leichmannii [1]. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Thus model identifies NrdJ enzymes only in cyanobacteria, lactococcus and certain bacteriophage. A separate model (TIGR02504) identifies a larger group of divergent B12-dependent RNR's. |
| References | RN [1]
RM PMID: 8397403
RT Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii.
RA Booker S, Stubbe J.
RL Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8352-6. |
| Genome Property | GenProp0284: cobalamin-utilizing enzymes (HMM) |
| | GenProp0290: class II (B12-dependent) ribonucleotide reductase (HMM) |
