HMM Summary Page: TIGR02505

Functionribonucleoside-triphosphate reductase, adenosylcobalamin-dependent
Gene SymbolnrdJ
Trusted Cutoff340.05
Domain Trusted Cutoff340.05
Noise Cutoff154.15
Domain Noise Cutoff154.15
Isology Typeequivalog
EC Number1.17.4.2
HMM Length724
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole Category2'-Deoxyribonucleotide metabolism
Gene Ontology TermGO:0016960: class II ribonucleotide reductase activity molecular_function
AuthorSelengut J
Entry DateMar 7 2005 1:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (RNR) related to the characterized species from Lactococcus leichmannii [1]. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Thus model identifies NrdJ enzymes only in cyanobacteria, lactococcus and certain bacteriophage. A separate model (TIGR02504) identifies a larger group of divergent B12-dependent RNR's.
ReferencesRN [1] RM PMID: 8397403 RT Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii. RA Booker S, Stubbe J. RL Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8352-6.
Genome PropertyGenProp0284: cobalamin-utilizing enzymes (HMM)
GenProp0290: class II (B12-dependent) ribonucleotide reductase (HMM)