HMM Summary Page: TIGR02504

Functionribonucleoside-diphosphate reductase, adenosylcobalamin-dependent
Trusted Cutoff399.95
Domain Trusted Cutoff399.95
Noise Cutoff398.35
Domain Noise Cutoff398.35
Isology Typeequivalog
EC Number1.17.4.1
HMM Length606
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole Category2'-Deoxyribonucleotide metabolism
Gene Ontology TermGO:0016960: class II ribonucleotide reductase activity molecular_function
AuthorSelengut J
Entry DateMar 7 2005 1:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus [1], Thermoplasma [2], Corynebacterium [3] and Deinococcus [3]. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ.
ReferencesRN [1] RM PMID: 9012808 RT Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes? RA Riera J, Robb FT, Weiss R, Fontecave M. RL Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):475-8. RN [2] RM PMID: 8990160 RT The B12-dependent ribonucleotide reductase from the archaebacterium Thermoplasma acidophila: an evolutionary solution to the ribonucleotide reductase conundrum. RA Tauer A, Benner SA. RL Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):53-8. RN [3] RM PMID: 6986368 RT The purification and characterization of an adenosylcobalamin-dependent ribonucleoside diphosphate reductase from Corynebacterium nephridii. RA Tsai PK, Hogenkamp HP. RL J Biol Chem. 1980 Feb 25;255(4):1273-8. RN [4] RM PMID: 9391052 RT B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli. RA Jordan A, Torrents E, Jeanthon C, Eliasson R, Hellman U, Wernstedt C, Barbe J, Gibert I, Reichard P. RL Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13487-92.
Genome PropertyGenProp0284: cobalamin-utilizing enzymes (HMM)
GenProp0290: class II (B12-dependent) ribonucleotide reductase (HMM)