| Accession | TIGR02504 |
| Name | NrdJ_Z |
| Function | ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent |
| Trusted Cutoff | 399.95 |
| Domain Trusted Cutoff | 399.95 |
| Noise Cutoff | 398.35 |
| Domain Noise Cutoff | 398.35 |
| Isology Type | equivalog |
| EC Number | 1.17.4.1 |
| HMM Length | 606 |
| Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
| Subrole Category | 2'-Deoxyribonucleotide metabolism |
| Gene Ontology Term | GO:0016960: class II ribonucleotide reductase activity molecular_function |
| Author | Selengut J |
| Entry Date | Mar 7 2005 1:52PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus [1], Thermoplasma [2], Corynebacterium [3] and Deinococcus [3]. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis.
This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. |
| References | RN [1]
RM PMID: 9012808
RT Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes?
RA Riera J, Robb FT, Weiss R, Fontecave M.
RL Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):475-8.
RN [2]
RM PMID: 8990160
RT The B12-dependent ribonucleotide reductase from the archaebacterium Thermoplasma acidophila: an evolutionary solution to the ribonucleotide reductase conundrum.
RA Tauer A, Benner SA.
RL Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):53-8.
RN [3]
RM PMID: 6986368
RT The purification and characterization of an adenosylcobalamin-dependent ribonucleoside diphosphate reductase from Corynebacterium nephridii.
RA Tsai PK, Hogenkamp HP.
RL J Biol Chem. 1980 Feb 25;255(4):1273-8.
RN [4]
RM PMID: 9391052
RT B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli.
RA Jordan A, Torrents E, Jeanthon C, Eliasson R, Hellman U, Wernstedt C, Barbe J, Gibert I, Reichard P.
RL Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13487-92. |
| Genome Property | GenProp0284: cobalamin-utilizing enzymes (HMM) |
| | GenProp0290: class II (B12-dependent) ribonucleotide reductase (HMM) |
