HMM Summary Page: TIGR02503

Functiontype III secretion chaperone SycN
Gene SymbolsycN
Trusted Cutoff84.55
Domain Trusted Cutoff84.55
Noise Cutoff37.05
Domain Noise Cutoff37.05
Isology Typeequivalog
HMM Length120
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
AuthorHaft DH
Entry DateMar 3 2005 3:24PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are part of the machinery of bacterial type III secretion in a number of bacteria that target animal cells. In the well-studied system from Yersinia, a complex of this protein (SycN) and YscB (PF07329) acts as a chaperone for the export of YopN (PMID:10094626). YopN then acts to control effector protein secretion, in response to calcium levels, so that secretion occurs only after contact with the targeted eukaryotic cell.
ReferencesRN [1] RM 10094626 RT A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis. RA Day JB, Plano GV. RL Mol Microbiol. 1998 Nov;30(4):777-88.
Genome PropertyGenProp0052: type III secretion (HMM)