HMM Summary Page: TIGR02486

Functionreductive dehalogenase
Trusted Cutoff160.35
Domain Trusted Cutoff160.35
Noise Cutoff132.25
Domain Noise Cutoff132.25
Isology Typesubfamily
EC Number1.97.1.-
HMM Length314
AuthorSelengut J
Entry DateFeb 24 2005 9:28AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases [1] found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase [2] ( which also acts on trichloroethene converting it to dichloroethene.
ReferencesRN [1] RM PMID: 11097881 RT Trichloroethene reductive dehalogenase from Dehalococcoides ethenogenes: sequence of tceA and substrate range characterization. RA Magnuson JK, Romine MF, Burris DR, Kingsley MT. RL Appl Environ Microbiol. 2000 Dec;66(12):5141-7. RN [2] RM PMID: 9224702 RT Redox chemistry of cobalamin and iron-sulfur cofactors in the tetrachloroethene reductase of Dehalobacter restrictus. RA Schumacher W, Holliger C, Zehnder AJ, Hagen WR. RL FEBS Lett. 1997 Jun 16;409(3):421-5.
Genome PropertyGenProp0284: cobalamin-utilizing enzymes (HMM)