HMM Summary Page: TIGR02485

Functionprecorrin 3B synthase CobZ
Gene SymbolcobZ
Trusted Cutoff372.55
Domain Trusted Cutoff372.55
Noise Cutoff180.55
Domain Noise Cutoff180.55
Isology Typehypoth_equivalog
HMM Length437
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0009236: cobalamin biosynthetic process biological_process
AuthorSelengut J
Entry DateFeb 24 2005 8:21AM
Last ModifiedFeb 14 2011 3:27PM
CommentCobZ is essential for cobalamin biosynthesis (by knockout of the R. capsulatus gene [1]) and is complemented by the characterized precorrin 3B synthase CobG. The enzyme has been shown to contain flavin, heme and Fe-S cluster cofactors and is believed to require dioxygen as a substrate. This model identifies the N-terminal portion of the R. capsulatus gene which, in other species exists as a separate protein. The C-terminal portion is homologous to the 2-component signal transduction system protein CitB (TIGR02484).
ReferencesRN [1] RM PMID: 15525640 RT Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors. RA McGoldrick HM, Roessner CA, Raux E, Lawrence AD, McLean KJ, Munro AW, Santabarbara S, Rigby SE, Heathcote P, Scott AI, Warren MJ. RL J Biol Chem. 2005 Jan 14;280(2):1086-94. Epub 2004 Nov 03.
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)