HMM Summary Page: TIGR02457

Functionputative maltokinase
Trusted Cutoff375.05
Domain Trusted Cutoff375.05
Noise Cutoff135.95
Domain Noise Cutoff135.95
Isology Typehypoth_equivalog_domain
HMM Length529
Mainrole CategoryEnergy metabolism
Subrole CategoryBiosynthesis and degradation of polysaccharides
Gene Ontology TermGO:0000023: maltose metabolic process biological_process
GO:0005991: trehalose metabolic process biological_process
GO:0016866: intramolecular transferase activity molecular_function
AuthorHaft DH
Entry DateFeb 3 2005 11:05AM
Last ModifiedJul 11 2012 11:04AM
CommentThree pathways for the biosynthesis of trehalose, an osmoprotectant that in some species is also a precursor of certain cell wall glycolipids. Trehalose synthase, TreS, can interconvert maltose and trehalose, but while the equilibrium may favor trehalose, physiological concentrations of trehalose may be much greater than that of maltose and TreS may act largely in its degradation. This model describes a domain found only as a C-terminal fusion to TreS proteins. The most closely related proteins outside this family, Pep2 of Streptomyces coelicolor and Mak1 of Actinoplanes missouriensis, have known maltokinase activity. We suggest this domain acts as a maltokinase and helps drive conversion of trehalose to maltose.
ReferencesRN [1] RM 15378530 RT Isolation of mak1 from Actinoplanes missouriensis and evidence that Pep2 from Streptomyces coelicolor is a maltokinase. RA Jarling M, Cauvet T, Grundmeier M, Kuhnert K, Pape H. RL J Basic Microbiol. 2004;44(5):360-73.