HMM Summary Page: TIGR02451

Functionanti-sigma factor, putative, ChrR family
Trusted Cutoff124.50
Domain Trusted Cutoff124.50
Noise Cutoff58.20
Domain Noise Cutoff58.20
Isology Typesubfamily
HMM Length216
Mainrole CategoryRegulatory functions
Subrole CategoryOther
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0016481: negative regulation of transcription biological_process
AuthorHaft DH
Entry DateFeb 1 2005 3:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe member of this family from Rhodobacter sphaeroides has been shown both to form a complex with sigma(E) and to negatively regulate tetrapyrrole biosynthesis. This protein likely contains (at least) two distinct functional domains; several smaller homologs (excluded by the model) show homology only to the C-terminal, including a motif PxHxHxGxE.
ReferencesRN [1] RM 10610760 RT The Rhodobacter sphaeroides ECF sigma factor, sigma(E), and the target promoters cycA P3 and rpoE P1. RA Newman JD, Falkowski MJ, Schilke BA, Anthony LC, Donohue TJ. RL J Mol Biol. 1999 Nov 26;294(2):307-20.