HMM Summary Page: TIGR02445

Functionacetyl-CoA C-acyltransferase FadA
Gene SymbolfadA
Trusted Cutoff591.00
Domain Trusted Cutoff591.00
Noise Cutoff418.20
Domain Noise Cutoff418.20
Isology Typeequivalog
EC Number2.3.1.16
HMM Length385
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryDegradation
Gene Ontology TermGO:0003988: acetyl-CoA C-acyltransferase activity molecular_function
GO:0009062: fatty acid catabolic process biological_process
AuthorRosovitz MJ, Haft DH
Entry DateJan 31 2005 2:42PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis subunit of the FadBA complex has acetyl-CoA C-acyltransferase (EC activity, and is also known as beta-ketothiolase and fatty oxidation complex, beta subunit. This protein is almost always located adjacent to FadB (TIGR02437). The FadBA complex is the major complex active for beta-oxidation of fatty acids in E. coli.
ReferencesRN [1] RM 2191949 RT Nucleotide sequence of the fadA gene. Primary structure of 3-ketoacyl-coenzyme A thiolase from Escherichia coli and the structural organization of the fadAB operon. RA Yang SY, Yang XY, Healy-Louie G, Schulz H, Elzinga M. RL J Biol Chem. 1990 Jun 25;265(18):10424-9. DR HAMAP; MF_01620; 84 of 84