HMM Summary Page: TIGR02440

Functionfatty oxidation complex, alpha subunit FadJ
Gene SymbolfadJ
Trusted Cutoff968.45
Domain Trusted Cutoff968.45
Noise Cutoff723.00
Domain Noise Cutoff723.00
Isology Typeequivalog
EC Number4.2.1.17
HMM Length699
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryDegradation
Gene Ontology TermGO:0003857: 3-hydroxyacyl-CoA dehydrogenase activity molecular_function
GO:0004300: enoyl-CoA hydratase activity molecular_function
GO:0008692: 3-hydroxybutyryl-CoA epimerase activity molecular_function
GO:0009062: fatty acid catabolic process biological_process
AuthorRosovitz MJ, Haft DH
Entry DateJan 26 2005 11:13AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers represent alpha subunit of multifunctional enzyme complex of the fatty acid degradation cycle. Plays a minor role in aerobic beta-oxidation of fatty acids. FadJI complex is necessary for anaerobic growth on short-chain acids with nitrate as an electron acceptor. Activities include: enoyl-CoA hydratase (EC,3-hydroxyacyl-CoA dehydrogenase (EC, 3-hydroxybutyryl-CoA epimerase (EC A representative is E. coli FadJ (aka YfcX) (SP:P77399). This model excludes the FadB of TIGR02437 equivalog hmm.
ReferencesRN [1] RM 12535077 RT A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway. RA Campbell JW, Morgan-Kiss RM, Cronan JE Jr. RL Mol Microbiol. 2003 Feb;47(3):793-805. DR HAMAP; MF_01617; 52 of 54