HMM Summary Page: TIGR02439

Functioncatechol 1,2-dioxygenase
Gene SymbolcatA
Trusted Cutoff392.00
Domain Trusted Cutoff392.00
Noise Cutoff192.45
Domain Noise Cutoff192.45
Isology Typeequivalog
EC Number1.13.11.1
HMM Length285
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0018576: catechol 1,2-dioxygenase activity molecular_function
GO:0019615: catechol catabolic process, ortho-cleavage biological_process
AuthorHaft DH
Entry DateJan 25 2005 5:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family known so far are catechol 1,2-dioxygenases of the Proteobacteria. They are distinct from catechol 1,2-dioxygenases and chlorocatechol 1,2-dioxygenases of the Actinobacteria, which are quite similar to each other and resolved by separate models. This enzyme catalyzes intradiol cleavage in which catechol + O2 becomes cis,cis-muconate. Catechol is an intermediate in the catabolism of many different aromatic compounds, as is the alternative intermediate protocatechuate. In Acinetobacter lwoffii, two isozymes are present with abilities, differing somewhat, to act on catechol analogs 3-methylcatechol, 4-methylcatechol, 4-methoxycatechol, and 4-chlorocatechol.
ReferencesRM 9260969 RT Cloning and characterization of two catA genes in Acinetobacter lwoffii K24. RA Kim SI, Leem SH, Choi JS, Chung YH, Kim S, Park YM, Park YK, Lee YN, Ha KS. RL J Bacteriol. 1997 Aug;179(16):5226-31.
Genome PropertyGenProp0711: catechol ortho-cleavage upper pathway (HMM)