HMM Summary Page: TIGR02436

Functionfour helix bundle protein
Trusted Cutoff24.00
Domain Trusted Cutoff24.00
Noise Cutoff23.30
Domain Noise Cutoff23.30
Isology Typesubfamily
HMM Length109
AuthorHaft DH
Entry DateJan 25 2005 1:43PM
Last ModifiedJan 3 2012 5:34PM
CommentThis family describes a protein of unknown function whose structure is a bundle of four long alpha helices. Some of the first members of this family were found encoded in the (atypically large) intervening sequence (IVS) of Leptospira 23S RNA, a region often present in the rRNA gene and removed during rRNA processing without re-ligation. However, this location is not conserved, and naming this protein as a 23S RNA protein is both confusing and inaccurate.
ReferencesRN [1] RM PMID:16948161 RT Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundles. RA Lin LY, Ching CL, Chin KH, Chou SH, Chan NL RL Proteins. 2006 Nov 15;65(3):783-6. RN [2] RM PMID:8341711 RT Intervening sequence with conserved open reading frame in eubacterial 23S rRNA genes. RA Ralph D, McClelland M RL Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6864-8.