HMM Summary Page: TIGR02434
Accession | TIGR02434 |
Name | CobF |
Function | precorrin-6A synthase (deacetylating) |
Gene Symbol | cobF |
Trusted Cutoff | 195.80 |
Domain Trusted Cutoff | 195.80 |
Noise Cutoff | 119.45 |
Domain Noise Cutoff | 119.45 |
Isology Type | equivalog |
EC Number | 2.1.1.152 |
HMM Length | 250 |
Author | Selengut J |
Entry Date | Jan 21 2005 10:19AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively [1]. This model identifies CobF in High GC gram positive, alphaproteobacteria and pseudomonas-related species. |
References | RN [1] RT Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans. RA Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F. RL J Bacteriol. 1993 Nov;175(22):7430-40. |
Genome Property | GenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM) |