HMM Summary Page: TIGR02426

Function3-carboxy-cis,cis-muconate cycloisomerase
Gene SymbolpcaB
Trusted Cutoff355.75
Domain Trusted Cutoff355.75
Noise Cutoff298.30
Domain Noise Cutoff298.30
Isology Typeequivalog
EC Number5.5.1.2
HMM Length338
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0047472: 3-carboxy-cis,cis-muconate cycloisomerase activity molecular_function
AuthorHaft DH
Entry DateJan 13 2005 9:39AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are 3-carboxy-cis,cis-muconate cycloisomerase, the enzyme the catalyzes the second step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate.
ReferencesRN [1] RM 15006791 RT Diverse organization of genes of the beta-ketoadipate pathway in members of the marine Roseobacter lineage. RA Buchan A, Neidle EL, Moran MA. RL Appl Environ Microbiol. 2004 Mar;70(3):1658-68.
Genome PropertyGenProp0273: protocatechuate degradation to beta-ketoadipate (HMM)