HMM Summary Page: TIGR02418

Functionacetolactate synthase, catabolic
Gene SymbolalsS
Trusted Cutoff551.10
Domain Trusted Cutoff551.10
Noise Cutoff509.25
Domain Noise Cutoff509.25
Isology Typeequivalog
EC Number2.2.1.6
HMM Length539
Mainrole CategoryEnergy metabolism
Subrole CategoryFermentation
Gene Ontology TermGO:0003984: acetolactate synthase activity molecular_function
GO:0006113: fermentation biological_process
GO:0045151: acetoin biosynthetic process biological_process
AuthorHaft DH
Entry DateJan 3 2005 12:24PM
Last ModifiedFeb 14 2011 3:27PM
CommentAcetolactate synthase (EC combines two molecules of pyruvate to yield 2-acetolactate with the release of CO2. This reaction may be involved in either valine biosynthesis (biosynthetic) or conversion of pyruvate to acetoin and possibly to 2,3-butanediol (catabolic). The biosynthetic type, described by TIGR00118, is also capable of forming acetohydroxybutyrate from pyruvate and 2-oxobutyrate for isoleucine biosynthesis. The family described here, part of the same larger family of thiamine pyrophosphate-dependent enzymes (PF00205, PF02776) is the catabolic form, generally found associated with in species with acetolactate decarboxylase and usually found in the same operon. The model may not encompass all catabolic acetolactate synthases, but rather one particular clade in the larger TPP-dependent enzyme family.
Genome PropertyGenProp0272: pyruvate fermentation to acetoin (HMM)