| Accession | TIGR02418 |
| Name | acolac_catab |
| Function | acetolactate synthase, catabolic |
| Gene Symbol | alsS |
| Trusted Cutoff | 551.10 |
| Domain Trusted Cutoff | 551.10 |
| Noise Cutoff | 509.25 |
| Domain Noise Cutoff | 509.25 |
| Isology Type | equivalog |
| EC Number | 2.2.1.6 |
| HMM Length | 539 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Fermentation |
| Gene Ontology Term | GO:0003984: acetolactate synthase activity molecular_function |
| | GO:0006113: fermentation biological_process |
| | GO:0045151: acetoin biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Jan 3 2005 12:24PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Acetolactate synthase (EC 2.2.1.6) combines two molecules of pyruvate to yield 2-acetolactate with the release of CO2. This reaction may be involved in either valine biosynthesis (biosynthetic) or conversion of pyruvate to acetoin and possibly to 2,3-butanediol (catabolic). The biosynthetic type, described by TIGR00118, is also capable of forming acetohydroxybutyrate from pyruvate and 2-oxobutyrate for isoleucine biosynthesis. The family described here, part of the same larger family of thiamine pyrophosphate-dependent enzymes (PF00205, PF02776) is the catabolic form, generally found associated with in species with acetolactate decarboxylase and usually found in the same operon. The model may not encompass all catabolic acetolactate synthases, but rather one particular clade in the larger TPP-dependent enzyme family. |
| Genome Property | GenProp0272: pyruvate fermentation to acetoin (HMM) |
