HMM Summary Page: TIGR02417

FunctionD-fructose-responsive transcription factor
Trusted Cutoff389.55
Domain Trusted Cutoff389.55
Noise Cutoff205.15
Domain Noise Cutoff205.15
Isology Typesubfamily
HMM Length327
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
AuthorHaft DH
Entry DateDec 28 2004 3:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family belong the lacI helix-turn-helix family (PF00356) of DNA-binding transcriptional regulators. All members are from the proteobacteria. Characterized members act as positive and negative transcriptional regulators of fructose and sucrose transport and metabolism. Sucrose is a disaccharide composed of fructose and glucose; D-fructose-1-phosphate rather than an intact sucrose moiety has been shown to act as the inducer.
ReferencesDR PFAM; PF00356; LacI DR PFAM; PF00532; Peripla_BP_1 RN [1] RM 8412665 RT Molecular analysis of two ScrR repressors and of a ScrR-FruR hybrid repressor for sucrose and D-fructose specific regulons from enteric bacteria. RA Jahreis K, Lengeler JW. RL Mol Microbiol. 1993 Jul;9(1):195-209. RN [2] RM 1805309 RT Sequence and evolution of the FruR protein of Salmonella typhimurium: a pleiotropic transcriptional regulatory protein possessing both activator and repressor functions which is homologous to the periplasmic ribose-binding protein. RA Vartak NB, Reizer J, Reizer A, Gripp JT, Groisman EA, Wu LF, Tomich JM, Saier MH Jr. RL Res Microbiol. 1991 Nov-Dec;142(9):951-63.